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Research Assistant in Modelling Physical Stability of Medicines (393210)

University of Strathclyde - Strathclyde Institute of Pharmacy and Biomedical Sciences

Location: Glasgow
Salary: £28,756 to £32,344
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 31st August 2021
Closes: 4th October 2021
Job Ref: 311501
 

Faculty of Science

Fixed (24 months)

CMAC is a world leading medicines manufacturing research centre that hosts a portfolio of collaborative research programmes aimed to transform the development and manufacture of medicines (www.cmac.ac.uk). Building on our long standing partnerships with a wide range of pharmaceutical manufacturers, we are excited to announce a new Community for Analytical Measurement Science (CAMS, https://cams-uk.co.uk) project with Pfizer and AstraZeneca on the development of advanced digital tools for the prediction of the physical stability of pharmaceutical solid oral dosage forms.

The use of predictive stability tools is growing across the pharmaceutical industry and specifically accelerated stability assessment program predictions are being used to support extended shelf life claims in regulatory submissions. Common oral solid dose medication produced by numerous pharmaceutical companies and consumed by the global population still have critical issues with respect to their safety and quality over their lifetime. The majority of oral solid dosage forms are designed to immediately release the active ingredient, where the pore structure and the disintegration process play a pivotal role in product performance.

This project aims to combine cutting-edge experimental methodologies (e.g. X-ray computed nanotomography, terahertz time-domain spectroscopy, optical coherence tomography) with multi-scale modelling (e.g. pore-scale modelling, cellular automata) approaches leading to innovative digital tools that are capable of predicting long-term changes of drug release kinetics. This will make a significant contribution towards the delivery of digitally enabled R&D, manufacturing and supply with benefits from shorter time to market, reduced cost, environmental impact and improved health.

We are currently seeking applicants for a Research Assistant based at the University of Strathclyde. This is a unique opportunity to help realise the next generation of development tools to accelerate and de-risk medicine development. You will work closely with experts from Pfizer and AstraZeneca and PhD students to deliver this exciting project.

You will have a Degree in a relevant subject (Mechanical Engineering, Chemical Engineering, Chemistry, Physics, Pharmaceutical Sciences or related discipline) with appropriate experience in modelling and microstructural characterisation ideally in a materials area to develop the digitally-driven technologies for predicting physical stability of tablets.

You must have excellent verbal and written communications skills and be able to work as a member of a research team. You should be able to manage your own activities and prioritise your own workload within agreed objectives to ensure that all activities are completed to deadlines.

Informal enquiries about the post can be directed to Dr Daniel Markl, PI, daniel.markl@strath.ac.uk.

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