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Postdoctoral Fellow - State-dependent Neural Processing Laboratory & Applied Biotechnology

The Francis Crick Institute

Location: London
Salary: £38,300 per annum, subject to skills and experience
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 15th November 2021
Closes: 12th January 2022
Job Ref: R370
 

Location: The Francis Crick Institute, Midland Road, London

Contract: Fixed Term (48 months), Full time

Salary: From £38,300 per annum, subject to skills and experience

Vacancy ID: R370

Short summary

This position is for a postdoctoral fellow in the State-dependent Neural Processing Laboratory led by Johannes (Jonny) Kohl. In close collaboration with Sam Rodriques’ Applied Biotechnology Laboratory, the postholder will seek to develop next-generation viral tracing approaches to interrogate the form and function of neural circuits. Suitable candidates should have a background in areas such as molecular, cellular or systems neuroscience, cellular/molecular biology or biotechnology.

Project summary

The  position is available in Johannes Kohl’s State-dependent Neural Processing Laboratory at the Francis Crick Institute, in close collaboration with Sam Rodriques’ Applied Biotechnology Laboratory. The Kohl lab uses a multidisciplinary approach, ranging from in vivo calcium imaging, electrophysiology, behavioural profiling and viral circuit tracing to investigate the neuronal and circuit mechanisms by which physiological states alter information processing in the brain. The Applied Biotechnology Laboratory works at the interface between academic bioengineering and biotechnology entrepreneurship. Its mission is to develop biotechnologies that address major unmet needs in biology and medicine and to put them into every laboratory or every clinic in the world.

The programme will be co-supervised by Jonny Kohl and Sam Rodriques who have highly complementary expertise in circuit neuroscience and biotechnology, respectively. The candidate will contribute to new, high-impact biotechnologies, while applying those technologies to answer fundamental questions in circuit neuroscience.

The goal of this project is to combine new, cell-type-specific viral vectors developed by the Rodriques lab with a new approach to viral circuit tracing developed by the Kohl lab in order to address major open questions in neuroscience. The successful candidate will develop novel viral reagents in collaboration with the Crick’s newly established Viral Vector Core, test these both in cell culture and in mouse models, and use these novel reagents to address open questions in circuit neuroscience.

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

  • If you are interested in applying for this role, please apply via our website.
  • The closing date for applications is 12 January 2022.
  • All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
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