|Salary:||£34,304 to £36,382 per annum (Grade 7)|
|Placed On:||22nd December 2021|
|Closes:||10th February 2022|
Full time 35 hours per week
4 year fixed-term contract
We are looking for an enthusiastic, motivated and highly skilled Postdoctoral Research Associate to join a dynamic and inclusive research environment in the computational biology group of Prof. Andrew Goryachev (goryachev.bio.ed.ac.uk).
A four-year postdoctoral position is available to theoretically study biophysical mechanisms of self-organized pattern formation in a semi-synthetic vertebrate system – the re-engineered frog oocyte. The project is a close collaboration with the cell and developmental biology experimental lab of W. Bement at the U. of Wisconsin, Madison. Earlier we described and analyzed spectacular waves of excitable and oscillatory dynamics on the surface of oocytes and embryos of frogs and echinoderms (Bement et al., Nat. Cell Biol., 17:1471, 2015). Since then, this natural phenomenon had been dramatically amplified by synthetic biology manipulations to generate complex wave patterns, unprecedented in any in vivo system, in the experimentally reproducible conditions. The project will further the mechanistic understanding of the phenomenon and focus on the control of pattern formation by, e.g., optogenetic approaches. As the biochemical machinery underlying the waves is the same as that powers actomyosin contractility and cell division, the project is closely related to the biomechanics of cellular cytoskeleton and cell shape regulation. The incumbent will perform advanced analysis of fluorescence microscopy data, development, implementation and analysis of biophysical models of complex spatiotemporal dynamics.
Your skills and attributes for success:
The University of Edinburgh is a charitable body, registered in Scotland, with registration number SC005336. Is e buidheann carthannais a th’ ann an Oilthigh Dhùn Èideann, clàraichte an Alba, àireamh clàraidh SC005336.
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