Postdoctoral Research Fellow

College of Medicine and Veterinary Medicine/Edinburgh Medical School/Deanery of Biomedical Sciences/Centre for Discovery Brain Sciences

Full Time: 35 Hours per Week

Fixed Term Contract: 3 years in the first instance

We are looking for a talented researcher to join our team at the UK Dementia Research Institute at the University of Edinburgh, within the lab of Centre Director Professor Giles Hardingham.

The Opportunity:

To drive a project aiming to determine how astrocytes change in response to Aß and tau pathology, the role that microglia play in mediating these changes, and the consequences of these changes. Ultimately this will lead to rescue strategies and therapeutic targets to modify patho-progression. The successful candidate will use established in vivo models of ß-amyloidopathy and tauopathy, including genetic models as well as the administration of human brain AD homogenate, plus mice lacking microglia (with and without microglial replacement therapy). Approaches will be tailored to the questions being asked, but may involve single-cell and spatial transcriptomics/proteomics, in vivo optical imaging, PET/MR, behavioural testing, electrophysiology and cell biological/primary culture approaches. All relevant training will be given. For examples of relevant publications see Jiwaji et al (2022) Nature Comm, Baxter et al (2021) Cell Reports, Rojo et al (2019) Nature Comm, Qiu et al (2018) Nature Prot, Hasel et al (2017) Nature Comm. For informal enquiries contact Giles.Hardingham@ed.ac.uk.

Your skills and attributes for success:

• A strong track record of research publications commensurate with career stage
• A high level of technical and theoretical knowledge in your current subject area.
• Ambition to develop a project and contribute intellectually to its direction
• Experience in a subset of relevant techniques
• Good interpersonal, time management and team-working skills

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