Postdoctoral Fellow

Location: The Francis Crick Institute, Midland Road, London

Short summary

We are seeking an enthusiastic and ambitious postdoctoral fellow to join the Tissue Regeneration and Clonal Evolution (TRCE) laboratory. We are a new multi-disciplinary research group with a mission to understand the factors underlying an organ’s regenerative capacity in order to design novel therapeutics to augment biological function.

We use the liver as a model organ since it has extraordinary regenerative abilities. We have identified several interesting genes in metabolic pathways which we hypothesise are important in allowing liver cells, called hepatocytes, to survive better in pathological conditions (Ng. et al, Nature, 2021).

The Project

In this research program, some of the specific aims include but are not limited to:

• Developing computational methods to model cell fate decisions in hepatocytes which regulate tissue regeneration
• Pioneering novel technology platforms for biological validation using bioengineered liver tissue and composite co-culture systems
• Combining cell free DNA technologies and machine learning algorithms to detect liver specific somatic mutation and epigenetic signatures during liver regeneration

Key Responsibilities

The postholder will be responsible for:

• Undertaking academic research and developing projects in a timely manner
• Adapting existing and developing new scientific techniques and experimental protocols
• Acquiring, analysing and reviewing scientific data to test and refine working hypotheses
• Providing guidance and training to less experienced members of the research group
• Actively contributing to preparation of scientific manuscripts and journal articles
• Working collaboratively with Crick Science Technology Platforms, bioengineers and clinical teams

Postdoctoral Fellows will lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential.

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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