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Postdoctoral Research Associate

Durham University - Department of Biosciences

Location: Durham
Salary: £37,099 to £44,263 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 3rd April 2024
Closes: 10th April 2024
Job Ref: 24000512

The Department

The Department of Biosciences is composed of academic staff and research fellows with research and teaching interests that span the broad spectrum of the Biosciences. The Department studies biology from the smallest to the largest scales; from the structures and functions of biological molecules, through to cells, tissues and organisms and to the entire global ecosystem. The interests of academic staff include all types of living organisms, from bacteria, through the plant and animal kingdoms, to human health and disease.

The Role

Inflammatory bowel diseases (IBD) are complex pathologies with an increasing worldwide prevalence. The scarcity and short-lived nature of IBD human tissue, low similarity between animal/human tissue, and absence of physiologically relevant in vitro models impedes research and drug development. We have bioengineered a reproducible, in vitro model that recapitulates aspects of the human IBD intestinal mucosa. These IBD models can be treated with appropriate stimuli to produce an inflammatory environment inducing endogenous cytokine secretion, impacts barrier function, and inflammatory events simulating key aspects of IBD. In this project we will refine our IBD in vitro assays and demonstrate their applicability for testing pharmaceutical compounds targeted against ameliorating IBD symptoms.

This six-month appointment to the MRC IAA grant requires specialist skills and knowledge for the bioengineering of human tissues.

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