Postdoctoral Researcher in Genetic Disorders of Chromatin Function

Location: Building for Genomic Medicine, Roosevelt Drive, Old Road Campus, Oxford, OX3 7BN

Salary: - Salary in range £36,024 - £40,521 per annum

Advert text – We have an exciting opportunity to recruit a Postdoctoral Researcher in genetic disorders of chromatin function to join Dr Robert Beagrie’s Lab at the Centre for Human Genetics, Nuffield Department of Medicine. This project will involve investigating the consequences of mutations in Nipbl. Nipbl is responsible for loading the cohesin complex onto chromatin and therefore has a major role in establishing proper 3D chromatin folding.

The project aims to characterize the transcriptional, epigenetic, and 3D-chromatin consequences of Nipbl disruption using animal models and cell lines. You will do this by applying advanced techniques including single-cell RNA-seq, single-cell ATAC-seq, and Genome Architecture Mapping (GAM).

You will be responsible for contributing to the research group’s goal of understanding how mutations in chromatin-organizing genes cause disease by conducting laboratory experiments to test hypotheses, reviewing and refining working hypotheses as appropriate, contributing ideas for new research projects, and developing ideas for generating research income. You will be tasked with keeping detailed, accurate, and comprehensible electronic records of experimental and computational work and communicating progress and difficulties in the research project to Dr. Beagrie and the wider research group. Finally, you will also be responsible for managing your own academic research and administrative activities, including small-scale project management and coordinating multiple aspects of work to meet deadlines.

To be successful in this role, you will hold a PhD/DPhil (or be close to completion) in biology, biochemistry, genetics, bioinformatics, or another related subject, along with strong experience in chromatin organization, gene regulation or congenital disease. You will have the ability to demonstrate a clear interest in learning how to generate Genome Architecture Mapping data and integrate it with single-cell and/or spatial transcriptomics data. You will also have the ability to work collaboratively as part of a team and manage the day-to-day running of a research project including assisting the work of junior researchers.

Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.

This position is offered full-time on a fixed-term contract for 2 years and is funded by Wellcome. 

Only applications received before 12 midday on Friday 13^th September 2024 will be considered. Interviews to be held on Thursday 10^th October. Please quote 174376 on all correspondence.

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