Research Assistant

Location: Aston University Main Campus

Contract Type: Fixed Term (24 months)

We are looking for a motivated research assistant to join Dr Dan Ma’s lab at Aston Medical School on a two-year Academy of Medical Sciences-funded project focused on neurodegeneration and stem cell biology. The study investigates how APOE4 expression in endothelial cells affects oligodendrocyte progenitor cells (OPCs), using iPSC-derived 3D co-culture models. This work aims to uncover cellular mechanisms of neurovascular dysfunction in Alzheimer’s disease and identify potential therapeutic targets. The successful candidate will be part of a collaborative team researching myelin protection in neurological disorders, building on recent publications by the group (Ma et al., Glia, 2024; Xu et al., Journal of Neurochemistry, 2025).

The role involves the culture and differentiation of iPSC lines into endothelial cells and OPCs, as well as conducting co-culture experiments to assess APOE4-related cellular interactions. It requires the use of molecular and cellular biology techniques, including immunocytochemistry, Western blotting, and qPCR, alongside the application of microscopic imaging techniques. Responsibilities also include data collection, analysis, and presentation, as well as contributing to the day-to-day running of the lab.

Candidates should hold a good BSc or MSc in Neuroscience, Cell Biology, Biomedical Science, Biochemistry, or a related discipline. Practical experience with mammalian cell culture is essential, ideally involving endothelial cells, OPCs, iPSCs, or neural cell models. Enthusiasm for neuroscience and neurodegenerative disease research is important, along with strong organizational, communication, and teamwork skills. The ability to work both independently and collaboratively within a team is also essential.

The successful candidate will receive training in advanced iPSC technologies, neurodegeneration models, and interdisciplinary collaboration. This is an exciting opportunity to contribute to a growing research programme with the potential to lead to PhD study or further career development in biomedical research. 

For informal enquiries, please contact Dr Dan Ma at d.ma@aston.ac.uk.

The salary being offered for this role is below the minimum threshold for required to sponsor new applicants to the Skilled Worker route. However, Aston University may be able to sponsor the successful candidate if they: 

•   Are under 26 years old
•   Hold a PhD that is relevant to the role
•   Have held a Student or Graduate visa in the last 2 years
•   Are already in the UK with a Tier 2 or Skilled Worker visa issued before April 4^th, 2024

Please contact hr_immigration@aston.ac.uk if you would like to discuss your eligibility for Skilled Worker sponsorship.

Closing Date: 23.59 hours BST on Saturday 31 May 2025

Interview Date: Monday 16 June 2025

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