Research Fellow (Post Doctoral)

Salary: Full time starting salary is normally in the range £36,130 to £45,413 with potential progression once in post to £48,149

Contract Type: Fixed Term contract up to July 2028

Background

A Wellcome Trust funded Post doctoral Research Fellow position is available in structural biology utilizing Cryo-EM, NMR and X-ray crystallography along with biochemistry, cell biology and RNA biology. The position will be based in the research group of Dr. Pravin Jagtap (https://www.jagtap-lab.com) at the University of Birmingham, UK. The Research Fellow will work in the field of RNA metabolism and regulation of gene expression to understand the regulatory mechanisms mediated by accessory domains in human RNA helicases involved in cancer and neurodegenerative diseases. We offer unique access to first-class instrumentation for structural biology. At the Midlands Regional Cryo Electron Microscope Facility in Leicester, you will have access to a 300kV Titan Krios G3 cryo-electron microscope with a direct electron-detecting camera. We have BAG access to the synchrotron at DIAMOND for small angle scattering and X-ray crystallography. At the national centre for biomolecular NMR spectroscopy in Birmingham (HWB-NMR), we host the best biomolecular NMR equipment available in the UK, comprising 1000 and 900 MHz spectrometers equipped with cryoprobes and MAS probes for both solution- and solid-state NMR, as well as an incoming 1.2 GHz spectrometer expected in spring 2025. Fully equipped biochemistry and molecular biology laboratories, as well as extensive equipment for in cellulo work and light microscopy are available. This interdisciplinary research environment will provide you with unique development opportunities.

Role Summary

• Work within specified research grants and projects and contribute to writing bids 
• Operate within area of specialism
• Design and perform experiments
• Analyse and interpret research findings and results 
• Contribute to generating funding 
• Contribute to licensing or spin out deals with demonstrated commercial success (such as revenues, asset or company sales, IP generated) and/or public understanding of the discipline or similar

Person Specification

• First degree in Chemistry, Biochemistry or Biophysics (or in any closely related area) and normally, a higher degree relevant to research area (Structural biology, biochemistry and biophysics) or equivalent qualifications
• PhD (or near to completion) in relevant subject area (structural biology or biophysics)
• Proficiency in at least one of these techniques (e.g., single-particle electron microscopy, NMR spectroscopy, X-ray crystallography, small-angle scattering) and willingness to learn others
• Experience in protein expression (bacterial, insect or mammalian cells), protein purification, and nucleic acid handling
• Experience with biophysical techniques for characterisation of protein-RNA, protein-protein and protein small molecule interactions

Informal enquiries can be made to Dr. Pravin Jagtap, email: p.k.a.jagtap@bham.ac.uk 

To download the full job description and details of this position and submit an electronic application online please click on the 'Apply' button above.

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