Research Associate (in Vitro)

Are you a postdoctoral researcher with a passion for neuroscience and drug discovery? We have an exciting opportunity at the Sheffield Institute for Translational Neuroscience (SITraN) for someone looking to apply their expertise in cell culture, molecular biology, and neurodegeneration to make a real impact in the fight against Motor Neurone Disease (MND/ALS).

You’ll join a collaborative and well-connected team working on a translational research project exploring the potential of Janus kinase inhibitors (Jakinibs) as neuroprotective agents. Using advanced human astrocyte-motor neuron co-cultures and iPSC and iNPC-derived neuronal assays, you’ll generate high-quality data to uncover mechanisms of neuroprotection and help drive forward therapeutic development.

What We’re Looking For
You’ll be educated to PhD level (or have equivalent experience) in neuroscience or a related field, with hands-on experience in mammalian cell culture, particularly iPSC/iNPC differentiation. You’ll be confident in immunocytochemistry, gene/protein expression analysis, and statistical data interpretation using tools like GraphPad Prism.

We’re looking for someone who:

• Works independently and collaboratively in a multidisciplinary team.
• Communicates effectively and keeps accurate scientific records.
• Is detail-oriented, organised, and motivated by translational impact.

Experience in drug screening, astrocyte-neuron co-culture assays, or supervising junior researchers would be a bonus.

Why Join Us?
SITraN is a world-leading research centre dedicated to tackling neurodegenerative diseases. Opened by Her Majesty the Queen and awarded the Queen’s Anniversary Prize, our institute brings together clinical and basic scientists in a purpose-built facility designed to accelerate discoveries from bench to bedside.

This role offers you the chance to:

• Develop highly transferable skills in drug discovery and translational neuroscience.
• Work with a team that has a proven track record of identifying molecules for clinical translation.
• Contribute to impactful research with real-world applications.

Advert information