PhD Studentship: Nanoengineered Slippery Coatings for Infection-Free Orthopaedic Implants

Supervisors:

Prof Manish Tiwari

Prof Shervanthi Homer-Vanniasinkam

Clinical Partner: The Royal National Orthopaedic Hospital (RNOH)

Collaborator: Dr. Priya Mandal – UCL Mechanical Engineering

Abstract:

Medical device-associated infections (MDAIs) are a major clinical and economic burden, particularly in orthopaedics where implant-related infections can lead to severe complications, including implant failure and limb amputation. Current antimicrobial coatings often rely on antibiotics or metallic agents, which may contribute to antimicrobial resistance (AMR) or cytotoxicity. This project aims to develop nanoengineered, slippery surface coatings that prevent bacterial adhesion and biofilm formation on orthopaedic implants without relying on antibiotics or toxic metals. By precisely tuning surface chemistry and nanoscale structure, these coatings will offer long-term, biocompatible protection against infection. The project will involve materials design, fabrication, characterisation, and biological testing, with clinical input from RNOH to ensure translational relevance.

Approach and Methods:

• Design and fabricate porous, nanoengineered surfaces with anti-adhesive, slippery properties
• Characterise surface morphology, chemistry, and mechanical durability
• Conduct biological assays to assess bacterial adhesion, biofilm formation, and cytocompatibility
• Collaborate with RNOH for clinical insight, testing platforms, and regulatory guidance
• Evaluate long-term performance and potential for clinical translation

Impact and Outlook:

This project addresses a critical unmet need in orthopaedic surgery by developing infection-resistant implant coatings that do not contribute to AMR. The technology has the potential to reduce infection rates, improve implant longevity, and lower healthcare costs. The approach may also be extended to other medical devices, supporting broader efforts to combat healthcare-associated infections.

Training and Student Development:

The student will gain interdisciplinary training in:

• Surface engineering and nano/microfabrication
• Materials characterisation techniques
• Microbiology and cell culture
• Translational research and clinical collaboration
• Regulatory considerations for medical devices

The student will work across UCL Mechanical Engineering and RNOH, benefiting from a collaborative environment and access to state-of-the-art facilities.

Research Environment:

The project is hosted in the Nanoengineered Systems Laboratory at UCL Mechanical Engineering, in collaboration with the Royal National Orthopaedic Hospital. The student will work closely with experts in porous materials, microbiology, and clinical translation, and will be supported by a multidisciplinary team spanning engineering, materials science, and healthcare.

Group link: Nanoengineered Systems Laboratory, UCL Mechanical Engineering

Desirable Prior Experience:

• Background in engineering, materials science, chemistry, or a related discipline
• Experience with surface fabrication, biomaterials, or microbiology is advantageous
• Interest in translational research and improving patient care

How to apply

This project is offered as part of the Centre for Doctoral Training in Engineering Solutions for Antimicrobial Resistance. Further details about the CDT and programme can be found at AMR CDT webiste  

Applications should be submitted by 12^th January 2026.

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