Research Fellow

The Microbial Biochemistry and Pathogenesis group of Professor Valvano, in the Wellcome-Wolfson Institute for Experimental Medicine, is looking for an ambitious, highly motivated individual with demonstrated research skills on cellular models of bacterial infection in macrophages, strong bioinformatics skills, molecular microbiology, and protein structure/function. The candidate will contribute to ongoing research aiming to understand the molecular and cellular pathogenesis of Enterobacter clinical isolates in the context of human infection.

About the person:

The successful candidate must have, and your application should clearly demonstrate that you meet the following essential criteria:

• Significant, recent research experience in state-of-the-art molecular and cellular infections in eukaryotic cells, microbiology, cell culture, and bioinformatic approaches to identify and characterisation of bacterial secretion systems.
• Extensive, recent, hands-on experience of using at least 3 standard molecular biology techniques (such as, but not limited to Gibson ligation, two-hybrid systems for protein-protein interaction, proteomics, etc.) to answer biological questions.
• Significant experience in handling Gram-negative bacterial pathogens relevant to the project.
• Demonstrated experience in culturing macrophages and epithelial cells.
• Recent experience with identification by confocal fluorescence microscopy imaging of intracellular compartments/organelles and associated bacteria.
• Demonstrated experience in protein bioinformatics, especially in silico modelling using AlphaFold or similar, clustering analysis techniques, gene synteny, etc.
• Experience teaching/supervising /mentoring postgraduate/ undergraduate/ school students and visiting researchers in the laboratory.
• Methodical approach to project management and meticulous regarding experimental procedures and record keeping

To be successful at shortlisting stage, please ensure you clearly evidence in your application how you meet the essential and, where applicable, desirable criteria listed in the Candidate Information document on our website.

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