Postdoctoral Research Assistant - the mechanisms of protein degradation

Location: Sir William Dunn School of Pathology, South Parks Road, Oxford

Contract: Fixed-term contract

We are seeking to appoint a Postdoctoral Research Assistant with a strong interest in addressing fundamental mechanistic questions in cell biology, biochemistry and/or structural biology. You will join a dynamic and supportive research group led by Prof. Pedro Carvalho and will play an active role in shaping the direction of the project.

The position would suit a well-trained, enthusiastic and self-motivated scientist interested in studying the molecular and mechanistic basis of ubiquitin-dependent protein degradation, with a particular emphasis on ERAD of membrane proteins. The project will involve the mechanistic dissection of protein quality control pathways, combining biochemical and cell-biological approaches, and, where appropriate, structural biology.

You will be responsible for managing your own research project while contributing conceptually to the overall research programme. This includes coordinating multiple aspects of the work, refining working hypotheses in light of new data, and contributing ideas for new research directions.

The post-holder should hold, or be close to completion of, a PhD in molecular/cell biology, biochemistry, structural biology or a closely related discipline. You should be able to think critically about experimental design, develop and test hypotheses, and integrate data from multiple approaches to address fundamental biological questions. Strong publication records as well as experience in protein biochemistry, including expression and purification of recombinant protein (membrane proteins in particular) are essential.

This is a fixed-term appointment available for 2 years. If you are interested in this role, and have the skills and experience we are looking for, please apply online. You will be required to upload a CV and supporting statement as part of your online application. Informal enquiries could be sent to Prof Pedro Carvalho via email: pedro.carvalho@path.ox.ac.uk .

The closing date for applications is 12.00 midday on Friday 27 February 2026. Interviews will be held as soon as possible thereafter.

At the Dunn School we are committed to supporting the professional and career development of our postdocs and research staff. To help them thrive and achieve their ambitions, we have created a comprehensive range of opportunities and initiatives designed to provide an exceptional launchpad for their future careers.

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