Senior Clinical Research Fellow

About us

The UCL Huntington’s Disease Centre, based in the Department of Neurodegenerative Disease at the UCL Queen Square Institute of Neurology, is led by Professor Sarah Tabrizi (Director) and Professor Gillian Bates (Co Director). Established in 2015 in a purpose-built environment, the Centre brings together laboratory based mechanistic research and clinical neuroscience to enable the translation of fundamental discoveries into early phase, first in human studies. The Centre integrates preclinical research, biomarker development and clinical trial delivery, including proof of concept studies conducted through the Leonard Wolfson Experimental Neurology Centre, ahead of larger multi-centre phase II and III clinical trials.

About the role

You will primarily support the clinical development aims of a range of antisense oligonucleotide, gene therapy, and small molecule huntingtin lowering trials led by Professor Sarah Tabrizi at the UCL Huntington’s Disease Centre in collaboration with UCLH and the Leonard Wolfson Experimental Neurology Centre (LWENC). Acting as Chief Sub-Investigator you will lead on the day-to-day management of all clinical trials led by Professor Tabrizi.

Key responsibilities include including training and supervision of Clinical Research Fellows working on the trials, providing information to patients about the studies ensuring informed consent is obtained from participants, performing clinical and neurological assessments in accordance with Good Clinical Practice (GCP), completing case report forms in accordance with study protocols, and responding to data queries and feedback from study monitoring. You will also perform lumbar punctures and associated procedures for cerebrospinal fluid (CSF) collection, as well as procedures relating to the intrathecal drug administration, and providing rare out-of-hours medical care/advice for trial participants. You will also participate in the multidisciplinary HD and neurogenetics clinics at the NHNN.

An honorary contract will be sought from UCLH NHS Foundation Trust, for which a DBS check will be required.

The post is available to start from 03 August 2026 and is supported by philanthropic funding for two years in the first instance.

There may be the possibility for a successful candidate that has their CCT to apply for a future Honorary Consultant appointment at UCLH NHNN, with concomitant NHS responsibilities, subject to NHS eligibility requirements and a successful Honorary Consultant interview process.

For a full job description please visit UCL’s online recruitment portal (https://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs) and search using vacancy reference B02-10533. To apply, please upload a current CV, complete the online application form, and use the supporting statement section or upload a cover letter to outline how you meet the essential and desirable criteria for the role. Please do not upload any additional attachments as these will not be considered by the selection panel.

We expect to hold interviews on 08 June 2026.

About you

You’ll be a registered medical practitioner permitted to practise in the UK, will have completed general medical training to ST6 or equivalent level, and have experience of working in Neurology and an interest in Huntington’s disease. Substantial experience of working in Huntington’s disease clinical trials, in-depth knowledge of GCP and clinical trial governance, and demonstrable experience and proficiency in lumbar puncture are also essential for this role.

What we offer

The role is offered in the range of £62,075 - £78,670 per annum including London Allowance, on the CL, RDPS, or StR scale, dependent on NHS contract and/or stage of clinical training.

Customer advert reference: B02-10533

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