Senior Research Fellow

About us

The mission of the UCL GOS Institute of Child Health is to maximise and advocate for the holistic health of all children, young people and the adults they will become, through world-class research, education and public engagement. The UCL GOS ICH, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children’s health research outside North America. The Institute offers world-class education and training across a wide range of teaching and life learning programmes which address the needs of students and professional groups who are interested in and undertaking work relevant to child health. GOS ICH holds an Athena SWAN Charter Gold Award.

About the role

An exciting opportunity has arisen for an enthusiastic Senior Research Fellow to join our dynamic team within the Molecular & Cellular Immunology Unit at UCL GOS ICH. The MRC Centre of Research Excellenc e in Therapeutic Genomics (MRC CoRE TG) is a £50 million, 14-year international initiative to mass-produce and deliver affordable genetic therapies for currently untreatable rare conditions. The research fellow will be part of a large, international, collaborative effort focused on therapy for rare genetic disorders and the group aims are to revolutionise how therapies are identified, developed, and brought to the clinic for rare genetic disorders of the blood, eyes, and brain The post will primarily be involved to assist in the development of scalable gene editing platform to engineer therapeutic T cells for clinical trials in inherited disorders. This post will form part of a large, international, collaborative effort focused on therapy for rare genetic disorders. The Senior Research Fellow will be expected to carry out GMP optimisation manufacturing which will include cell culture, set-up, running, analysis of quality control, process validations and completion of all accompanyin g documentation including writing SOPS. This post will focus on genome-targeted therapies, primarily CRISPR-based genome editing techniques, that use genetic code to target specific genes. Genome-targeting brings specificity, by treating the genetic cause the disorder, but also flexibility, since a successful therapy could be ‘reprogrammed’ to another disorder in the same tissue by changing just the genetic code used for targeting. This is a research project focused on rare diseases.

About you

An experienced postdoc, highly motivated and capable individual with prior Knowledge and experience in gene editing and CRISPR/Cas system. Experience in LAM-PCR, NGS, qPCR essential. Please see attached JD/ PS for detailed information.

What we offer

Visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more.

Our commitment to Equality, Diversity and Inclusion

As London’s Global University, we know divers ity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce. You can read more about our commitment to EDI here : https://www.ucl.ac.uk/equality-diversity-inclusion/ For any queries contact quoting job reference

Customer advert reference: B02-11069

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