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Research Assistant (Fixed Term)

University of Cambridge - Cancer Research UK Cambridge Institute

The Brenton research group is located at the Cancer Research UK Cambridge Institute University of Cambridge. The Institute is core-funded by Cancer Research UK and has state-of-the-art research facilities for over 20 research groups to undertake world-class research into all aspects of cancer biology.

Ovarian cancer is the 4th commonest cause of female cancer related deaths. The research aims of our laboratory are to identify therapeutically relevant mechanisms of drug resistance in patients with ovarian cancer using genomic and functional approaches. We are using next-generation sequencing methods to identify novel, therapeutically relevant, copy number signatures associated with particular mutational processes in patient samples and developing plasma biomarkers of response based upon circulating tumour DNA.

We are looking for a Research Assistant to support genomic projects in the lab based around next-generation sequencing of patient tissues, body fluids and established cell lines.

Your primary responsibility will be for supporting translational research projects which will include but will not be limited to;

  • Handling of primary human tissue (frozen and paraffin-embedded) and extraction of nucleic acids.
  • Genomic profiling using shallow whole genome sequencing, tagged amplicon deep sequencing and mutation analysis.
  • Library preparation for next-generation sequencing: whole genome sequencing library preparation, tagged amplicon deep sequencing and detection of low prevalence mutations in plasma.
  • Assay design and optimization for quantitative PCR assays on RNA and DNA and targeted amplicon deep sequencing. Day to day samples management
  • Previous experience with database (Access, SQL) and programming skills (R language, Unix) are highly desirable but not essential
  • Secondary duties include routine laboratory management tasks.

About You

This post requires a bachelor's degree in a biological science, and sound knowledge of genomic and molecular biology techniques including mutation analysis, molecular biology techniques, standard cell culture and bioinformatics analysis of sequence variants. The successful applicant will be able to provide examples of being both a good team player and the ability to work independently. Excellent communication and organization skills are essential.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

To apply online for this vacancy and to view further information about the role, please visit:

The closing date is 12 June 2019, with the interview date TBC.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SW19142 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Location: Cambridge
Salary: £26,243 to £30,395 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 16th May 2019
Closes: 12th June 2019
Job Ref: SW19142
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