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Postdoctoral Research Fellow in Molecular Virology

University of Surrey - School of Biosciences & Medicine

Location: Guildford
Salary: £32,817 to £38,017 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 7th July 2021
Closes: 31st July 2021
Job Ref: 038421

Applications are invited for a 3-year post-doctoral position within the molecular virology group led by Dr Carlos Maluquer de Motes at the University of Surrey (United Kingdom). The post is funded by a BBSRC project grant aimed at studying the role of novel ubiquitin ligases in airway inflammation and viral infection.

In recent years, the group has identified cellular mechanisms that activate immune responses and how these are modulated by ubiquitin ligases as well as viruses. For a flavour of what we do, please see references below. We are now seeking to characterise several ubiquitin ligases identified in an unbiased screen as novel regulators of innate immunity and inflammation in the airway, and to determine whether these newly identified cellular ligases contribute to antiviral responses and/or are targeted by viruses. The candidate will use traditional biochemical and cellular assays to study protein-protein interactions, ubiquitylation, and innate immunity, together with state-of-the-art transcriptomics, proteomics and imaging. In addition, the candidate will train in the use of, and apply, several model viruses as part of a collaboration with the Pirbright Institute. This is therefore an exciting multi-angle project ideal for an ambitious scientist interested in the interface between immunity, viruses and the ubiquitin system.

  • Maluquer de Motes, C (2021) PLOS Pathogens, 17:e1009372. PMID 33735254.
  • Hernaez et al. (2020) Science Advances, 6:eabb4565. PMID 32948585.
  • Georgana et al. (2020) Frontiers in Immunology, 10:3121. PMID 32038638.
  • Gutierrez-Merino et al. (2020) Gut Microbes, 11:711. PMID 31941397.
  • Odon et al. (2018) Journal of Virology, 92:e01374-18. PMID 30258003.

We are aiming to appoint a motivated and inquisitive scientist with relevant skills for the project, able to lead a project individually and as part of a team. We are expecting you to have:

-       A PhD in Molecular Biology, Biochemistry, Virology, Immunology, or a related field;

-       A strong publication record (commensurate to your career stage and experience) with at least one first-author publication;

-       Expertise in any of the relevant areas of research (innate immunity, virology, ubiquitin system);

-       An inquisitive and innovative mind striving to accomplish high quality work;

-       Experience supervising graduate and/or undergraduate students and working as part of a team;

-       Excellent organisational, communication and interpersonal skills;

The candidate will be joining a group consisting of one post-doctoral researcher and 4 PhD students (at different stages of their studies). We are based at the School of Biosciences and Medicine (SBM), which facilitates access to state-of-the-art facilities and brings an international collegiate mass of researchers dedicated to the multidisciplinary study of human health, including specific sections for virology, bacteriology, immunology, biochemistry and systems biology. The Virology Section is an expanding unit with 5 independent group leaders with complementary interests in multiple aspects of virus biology including entry and morphogenesis; transcription and translation; transmission; and immune evasion.

For informal enquiries e-mail Dr Carlos Maluquer de Motes via: c.maluquerdemotes@surrey.ac.uk.

Further details:

For more information and to apply online, please download the further details and click on the 'apply' button above.
The University of Surrey is committed to providing an inclusive environment that offers equal opportunities for all.  We place great value on diversity and are seeking to increase the diversity within our community.  Therefore we particularly encourage applications from under-represented groups, such as people from Black, Asian and minority ethnic groups and people with disabilities.

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