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Research Associate

Imperial College London - Department of Infectious Disease

Location: London
Salary: £41,593 to £49,210 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 2nd September 2021
Closes: 23rd September 2021
Job Ref: MED02693
 

Location: Full-time, Fixed-term from 1st October 2021 until 30th September 2024 and based at our St Mary’s Campus.

Job Summary

Applications are invited for the post of post-doctoral Research Associate in the Section of Virology within the Department of Infectious Disease, Imperial College London.

Human immunodeficiency virus and human T-cell lymphotropic virus type 1 (HTLV-1) are the most notorious retroviruses since they are the cause of severe, disabling and sometimes fatal diseases. Ten to 20 million people worldwide are infected with HTLV-1. Of these individuals, about 10% will become ill. The most severe HTLV-1 induced diseases are a neurological inflammatory disease and an aggressive form of leukaemia-lymphoma. So far, no good treatments of HTLV-1 infected patients are available. Patients diagnosed with leukaemia typically die within two years of presentation.

One essential step in the life cycle of retroviruses, such as HTLV-1, is the insertion of a copy of the viral genome into the host DNA. This process is executed by the viral integrase protein. We recently identified a host factor for HTLV-1 integration, PP2A-B56 (Maertens, G.N. NAR 2016; Barski, M.S. et al Nat. Comms, 2020). This project focuses on understanding the contribution and mechanics of the PP2A-B56 host factor in establishing HTLV-1 infection.

Duties and responsibilities

The position is supported by the Medical Research Council. You will focus on characterising the role and mechanism of host factors in HTLV integration. Various genetic, molecular and biochemical techniques, including next generation sequencing (NGS), DamID-seq, ChIPseq and RNAseq approaches will be used. You will be in an excellent position to carry out research in the competitive field of retrovirology.

Essential requirements

The project requires an exceptionally motivated scientist with a PhD in a relevant area, and a solid background in molecular biology and biochemistry techniques, preferably with experience in retrovirology.

Good experience with RNA sequencing and NGS analysis, working with R and/or experience with molecular retroviral work would be an advantage. You will have the opportunity to design and implement experimental strategies and to develop the project.

You will have good interpersonal and presentation skills and will also be required to train/assist other members of the laboratory. In addition, you will be expected to submit publications to refereed journals, and to present your findings at international and national conferences.  

Further information

For more information on the background of the project, visit this website:

https://www.imperial.ac.uk/people/g.maertens

Informal enquiries may be made to Dr Goedele N. Maertens at g.maertens@imperial.ac.uk

Disclosure and Barring Service (DBS) check if required

As this post is exempt from the Rehabilitation of Offenders Act 1974, a satisfactory Disclosure and Barring Service (DBS) check, at the appropriate level, will be required for the successful candidate.

Further information about the DBS disclosure process can be found at https://www.homeoffice.gov.uk/agencies-public-bodies/dbs/ or by telephoning 03000 200 190. You may also wish to view the College’s DBS webpage for policy statements on the Recruitment and Employment of Ex-Offenders and the Secure Storage, Use, Retention & Disposal of Disclosures and Disclosure Information.

To apply, visit www.imperial.ac.uk/jobs and search by the job reference MED02693

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