Research Scientist

Location: Hawkshead (nr Potters Bar, Herts)

Fixed Term / Full Time

Closing Date: 10/02/2023

Interview Date: 21/02/2023 

Research Scientist in Equine Functional Genomics – 36 months Fixed term 

We are recruiting a research scientist (fixed term, 36 months) to join an expanding genetic and genomics group at the Royal Veterinary College and to work on a highly prevalent disorder of horses. Recurrent exertional rhabdomyolysis (RER) is a common syndrome characterised by painful episodes of exercise induced muscle stiffness and contracture, myofibre necrosis, myoglobinuria, and sometimes renal failure and death. RER affects humans and many animal species, but racehorses appear particularly predisposed. Despite significant welfare and financial implications, in most cases the underlying aetiopathogenesis remains unknown and currently there is no treatment. This project aims to address this issue and dissect the genomic architecture of equine RER by generating and comparing multi-omics data of RER cases and controls. Based at the RVC, the post-holder will implement single cell RNA-Seq, ATAC-Seq and 3D genomics approaches to generate cutting edge data on equine muscle regulation and expression, and will combine it with available RER genetic and genomic data to prioritise genomic and epigenetic biomarkers for RER susceptibility.

The key findings will be further validated using wet lab techniques such as RNAscope and immunohistochemistry. The post-holder will join a multidisciplinary team linking researchers at the RVC with University of Edinburgh, University of Minnesota, and industry. The project will provide the opportunity for the successful candidate to travel to international scientific conferences and meet with international collaborators. This post will require a research scientist who is experienced in wet lab and next generation sequencing analysis. Previous experience of working in a veterinary or equine context will be advantageous, but not essential.

We are looking for candidates with a PhD qualification in animal genomics/bioinformatics. Detailed below are the job description, person specifications and qualifications listing the essential and desirable requirements for the post, which will be used as the basis for the shortlisting.

Prospective applicants are encouraged to contact Dr Androniki Psifidi on +44 1707 669252 or email: apsifidi@rvc.ac.uk for further clarifications.

We offer a generous reward package.

For further information and to apply on-line please visit our website: www.rvc.ac.uk

Job reference CSS-0356-22

We promote equality of opportunity and diversity within the workplace and welcome applications from all sections of the community.

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