Postdoctoral Research Scientist (Cell Communication & Redox Signalling)

The Babraham Institute is a charity which is world renowned for its research in life sciences to enhance lives and improve wellbeing. The overarching goal of the Sharpe lab is to understand intercellular communication across different systems, with a focus on how changes in metabolic and redox states are sensed by the phosphotyrosine machinery in cells. 

Purpose

We are looking to welcome a new ERC-funded postdoctoral research scientist to our team to work on molecular mechanisms of protein oxidation and their influence on cellular signalling and fates. Redox sensing by specific protein cysteines is a fundamental part of cell communication that operates with exquisite selectivity and timing. In addition, these processes are known to become dysregulated in disease and ageing, ultimately giving scope for identification of new pathways to target therapeutically.

We have a number of observations of specific redox-mediated conformational changes in proteins that will influence downstream signalling in, as yet, unappreciated ways. This role is suitable for researchers interested in translating insights from protein biochemistry to understanding cellular processes. There is also potential for collaborative structural studies on protein complexes.

The post-holder will benefit from world-class research facilities, the collegial environment of the Institute and the wider scientific research community in the Cambridge area.

The ideal candidate will hold a PhD in biochemistry, molecular/cell biology, or a relevant subject; and their expertise may include research experience with cell signalling, imaging, protein biochemistry, phosphatases, kinases or redox/thiol biology.

This is a limited term appointment with funding for this post available for a period of 3 years in the first instance.

A full job specification and role requirements can be found attached to this vacancy.

Informal enquires can be addressed to Hayley Sharpe (Hayley.sharpe@babraham.ac.uk)

For more information on the work of the group, please visit: https://www.babraham.ac.uk/our-research/signalling/hayley-sharpe

https://www.babraham.ac.uk/news/2023/11/hayley-sharpe-receives-erc-consolidator-grant

Applicants must hold a PhD or have their thesis submitted when commencing the post. Please note that you will be appointed on the starting salary of £34,500 per annum, if you have not yet been awarded your PhD.  All newly appointed postdocs will commence on the salary/scale point that reflects the number of years' post-PhD experience they hold on 30th June in the calendar year they commence employment.

Closing date for applications is Sunday 1^st September 2024. However, we reserve the right to close the vacancy early depending on the volume of applications received.

For further details about this position or to apply online click on the ‘Apply’ button above.

The Babraham Institute welcomes applications from all sections of society.

NO AGENCIES PLEASE

The Babraham Institute holds a silver Athena SWAN award and is committed to promoting and developing a culture of excellence, diversity and mutual respect that supports the Institute’s ambitions and attracts highly motivated and talented people.

The Babraham Institute abides by the principles of the government’s Disability Confident Scheme and has a positive approach to employing disabled people.

The Babraham Institute receives strategic funding from the Biotechnology and Biological Sciences Research Council and is an Equal Opportunities Employer.

Advert information