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Senior Research Assistant - Protein/VLP Purification

University of Oxford - Nuffield Department of Medicine

Location: Oxford
Salary: £32,817 to £40,322 p.a. (Grade 7)
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 3rd December 2019
Closes: 2nd January 2020
Job Ref: 144263

Nuffield Department of Medicine, Jenner Institute, Old Road Campus Research Building, Headington, Oxford

We are seeking to appoint an experienced Senior Research Assistant to support the Transmission-blocking malaria vaccine development group, led by Professor Sumi Biswas.

You will be performing research work in molecular biology, protein and VLP production including: PCR, plasmid cloning, fermentation, tissue culture, chromatography purification and analysis of protein vaccine preparations. Support the program of vaccine development within the group, with a particular emphasis on recombinant protein and virus-like particle production, purification and QC analysis. Lead and develop the research programme to develop vaccines for the malaria vaccine groups. Investigate, develop and establish new methodologies that can be applied to the production, purification and/or QC of new protein and VLP vaccine candidates. Assist with laboratory supervision and training of new students or other members of staff in protein and VLP vaccine production, purification and QC methods.

You will have a degree in a relevant biological subject. The ability to interpret and analyse complex scientific data, experience in planning multiple projects and possess excellent organisational and interpersonal skills. Advanced skills in working with specific VLPs, especially HBsAg and strong purification skills, preferably with the AKTA chromatography system are desirable. Ideally, you are experienced in cell-line development, microbial fermentation and antibody ELISA assays. Understanding of EU GMP and experience in the GMP process development would also be desirable.

You will be required to upload a CV and supporting statement which explains how you meet the selection criteria for the post.

This post is offered full-time on a fixed-term contract for 24 months in the first instance. This position is funded by European Union. Please quote reference 144263 on all correspondence.

Only applications received before 12.00 noon on 2 January 2020 will be considered.

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