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Research Associate

University of Sheffield - Department of Neuroscience

Location: Sheffield
Salary: £31,866 to £40,322 per annum. Potential to progress to £44,045 per annum through sustained exceptional contribution
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 7th April 2021
Closes: 29th April 2021
Job Ref: UOS028149

Contract Type: Fixed-term for 2 years to start as soon as possible.

Working Pattern: Full-time

Closing Date: 29 April 2021

Applications are invited for the post of Research Associate to work on an exciting translational drug discovery program funded by the Darby Rimmer MND Foundation ( which aims to discover and develop novel small molecule drugs for the treatment of amyotrophic lateral sclerosis (ALS). You will join the research teams of Prof Kurt De Vos and Prof Dame Pamela Shaw based in the Sheffield Institute for Translational Neuroscience (SITraN; at the University of Sheffield.

You will conduct laboratory research on a semi-independent basis under direction of Profs De Vos and Shaw and the manager of the SITraN drug discovery facility, focussing on the implementation, validation and application of a novel drug discovery assay. You will be expected to design and evaluate experiments, develop new ideas that promote current research, contribute to the preparation of scientific manuscripts, attend and give seminars. You will participate in the application for funding to support research assistants and in the supervision of graduate and undergraduate research that contributes to this project. You may be responsible for the operation of specific equipment and asked to serve on internal Institute committees.

You will have a PhD (or be close to completion) in a relevant field of neuroscience, molecular or cellular biology or equivalent experience. You should also have a strong background in molecular and cellular neurobiology with a thorough understanding of the molecular basis of neurodegeneration and the drug discovery process. You will have experience in an array of molecular and cellular biology techniques, particularly relating to protein homeostasis. The ideal candidate will have experience in cellular assays in multi well plate format using biochemistry and high content screening. Experience of high throughput fluorescence imaging as well as good knowledge and practical experience in drug discovery, including development, implementation, validation and application of drug discovery assays, would be an advantage.

The candidate should be strongly motivated, self-driven, able to accept direction and be an excellent team player. Good communication, written and interpersonal skills are expected.

We’re one of the best not-for-profit organisations to work for in the UK. The University’s Total Reward Package includes a competitive salary, a generous Pension Scheme and annual leave entitlement, as well as access to a range of learning and development courses to support your personal and professional development.

We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.

To find out what makes the University of Sheffield a remarkable place to work, watch this short film:, and follow @sheffielduni and @ShefUniJobs on Twitter for more information.

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