Postdoctoral Research Associate

Fixed-term: available until 30^th September, 2024, with possibility to extend for 6 months, dependent on grant extension, application currently in progress

A postdoctoral research associate position is available to work on recapitulation of morphogenesis of the embryonic dorsal aorta using human ES cell cultures with the aim to reproduce the process of the endothelial-to-haematopoietic transition (EHT).

The Opportunity:

The successful candidate will join Alexander Medvinsky’s group. The study is built on their long-standing expertise in the area of developmental haematopoiesis in the mouse and human (https://www.ed.ac.uk/regenerative-medicine/research/alexander-medvinsky).

You will use transgenic reporter hES cell lines in order to explore effects of micro environmental / mechanical cues and signalling molecules on specification and self-organisation of the dorsal aorta and on the EHT. Micro patterned substrates will be employed to enhance precision and manipulation of culture conditions (collaboration with Dr Guillaume Blin, “Quantitative Biology of Pattern Formation” group, https://www.ed.ac.uk/regenerative-medicine/research/guillaume-blin).

You are encouraged to apply if you have expertise in developmental biology, cell signalling, cell culture and imaging. The position is available for 18 months with potential extension for 6 months.

Our laboratory aims to understand mechanisms underlying development of haematopoietic stem cells (HSCs), using human embryonic AGM region and differentiating ES cells.

The post holder will work closely with other members of our laboratory, with technical and bioinformatics support.

For informal enquiries please contact the hiring manager -  Alexander Medvinsky at  a.medvinsky@ed.ac.uk or the School of Biological Sciences Staffing / HR Team at SBS.Contracts@ed.ac.uk.

Your skills and attributes for success:

• Expertise in developmental biology, confocal imaging and molecular biology.
• Experience in in vitro differentiation of human ES cells.
• Highly motivated.
• Good team player.
• Excellent communication skills.

Click here for a copy of the full job description.

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