Post-doctoral Research Associate (Cancer Research UK)

About the Role
We are looking for a Post-Doctoral Research Associate to join Mishto lab in the Centre for Inflammation Biology and Cancer Immunology (CIBCI) at King’s College London and in the Francis Crick Institute.

We are undertaking work on a number of projects relating to antigen presentation and T cell response in cancer and inflammation with the aim to further characterise the underlying molecular mechanisms and identify potential diagnostic and therapeutic targets.

If successful, the key areas of work that you will focus on include:

• Melanoma and pancreatic adenocarcinoma (PDAC) funded by Cancer Research UK Programme Foundation Award (CRUK-PFA) for 6 years. PI: Mishto. The name of the project is: Identification of tumour-specific spliced epitopes to target large cohorts of cancer patients by immunotherapies. 

The successful candidate will be expected to lead under the PI supervision a programme, whose aims includes:

• Discovery noncanonical (mutated) epitopes relevant in cancer immunotherapy.
• Isolating CD8+ T cell clones specific for HLA-I-restricted neoepitopes carrying recurrent driver mutations in cancer, and cloning their TCRs to investigate the epitope generation in cancer cells.
• investigate the neoepitope antigenicity in peripheral blood of cancer patients.
• Validating the epitope candidates in xenograft in vivo mouse model.

You will have opportunities to interact with national and international collaborators with a broad expertise, which varies from computational biology to clinics. 

You will be working on a full-time basis (35 hours per week) and offered a fixed term contract until September 2025. 

About Us

This is a research support post in the Mishto lab within the Centre for Inflammation Biology and Cancer Immunology (CIBCI) at the Guy’s campus of King’s College London and at the Francis Crick Institute.

CIBCI is focusing on research that aspires to advance the fundamental and applied knowledge of the biology, diagnosis and treatment of inflammation, its associated pathologies, and its bearing on tumour immunobiology.

The Francis Crick Institute is a biomedical research institute working with organisation across academia, medicine and industry to make discoveries about how life works.

About you

If this area of research sounds of interest, we would be interested in hearing from you.

Our ideal candidate will be able to demonstrate how they meet the following criteria:

Essential criteria  

1. A PhD in Cell or Molecular Biology, Biochemistry, Immunology or a related subject (Application)
2. Experience of mammalian cell culture (Application)
3. Excellent knowledge and understanding in either of these areas: Cell biology, molecular immunology, antigen presentation, T and B cell biology (Application)
4. Track record of peer-reviewed scientific publications (Application)
5. Effective time management and organisational skills
6. Ability to communicate effectively with researchers
7. Ability to manage a busy research project

Desirable criteria

1. Experience of working with cell culture, molecular and cell biology projects, antigen presentation, T and B cells (Application)
2. Experience of working with flow cytometry (Application)
3. Extensive experience in modern cellular, molecular biology, biochemistry and imaging techniques 
4. Experience of T Cell clone generation and maintenance 
5. Experience of in vivo experiments on mouse models 

Application Process

Please submit a personal statement when applying for this vacancy, clearly setting out how you meet the essential criteria, as this is how we shortlist applications.

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