Post-doctoral Research Associate (Blood Cancer UK)

About the Role
We are looking for a Post-Doctoral Research Associate to join us in the Centre for Inflammation Biology and Cancer Immunology (CIBCI).

We are undertaking work within two groups who are working on a number of projects relating to antigen presentation and T cell response in cancer and inflammation with the aim to further characterise the underlying molecular mechanisms and identify potential diagnostic and therapeutic targets. 

If successful, the key areas of work that you will focus on include. The focus of the post will be to carry out a project on:

• Myeloproliferative neoplasia (MPN) funded by Blood Cancer UK (BCUK)
• Discovery noncanonical (mutated) epitopes relevant in cancer immunotherapy. 
• Isolating CD8+ T cell clones specific for HLA-I-restricted neoepitopes carrying recurrent driver mutations in cancer, and cloning their TCRs to investigate the epitope generation in cancer cells.
• Investigate the neoepitope antigenicity in peripheral blood of cancer patients.
• Validating the epitope candidates in xenograft mouse model. This task is limited to the project funded by CRUK.  

The successful candidate will have opportunities to interact with national and international collaborators with a broad expertise, which varies from computational biology to clinics, as well as Mishto lab at the Francis Crick Institute (London, UK). 

About Us

This is a research support post in the Mishto lab within the Centre for Inflammation Biology and Cancer Immunology (CIBCI) at the Guy’s campus of King’s College London. This post is also shared with Kordasti lab at the Comprehensive Cancer Centre at the Guy’s campus of King’s College London and could include experiments carried out at the Francis Crick Institute in Mishto lab. 

The centre is focusing on research that aspires to advance the fundamental and applied knowledge of the biology, diagnosis and treatment of inflammation, its associated pathologies, and its bearing on tumour immunobiology. Our collective aim is to identify key mechanisms and pathways underlying inflammation and cancer and to create opportunities for novel treatments for human disease.

About you

If this area of research sounds of interest, we would be interested in hearing from you.

Our ideal candidate will be able to demonstrate how they meet the following criteria:

Essential criteria  

1. A PhD in Cell or Molecular Biology, Biochemistry, Immunology or a related subject  
2. Experience of mammalian cell culture(Application)
3. Excellent knowledge and understanding in either of these areas: Cell biology, molecular immunology, antigen presentation, T and B cell biology (Application)
4. Track record of peer-reviewed scientific publications (Application)
5. Effective time management and organisational skills 
6. Ability to communicate effectively with researchers 
7. Ability to manage a busy research project

Desirable criteria

1. Experience of working with cell culture, molecular and cell biology projects, antigen presentation, T and B cells (Application)
2. Experience of working with flow cytometry (Application)
3. Extensive experience in modern cellular, molecular biology, biochemistry and imaging techniques 
4. Experience of T Cell clone generation and maintenance 
5. Experience of in vivo experiments on mouse models 

Application Process

Please submit a personal statement when applying for this vacancy, clearly setting out how you meet the essential criteria, as this is how we shortlist applications

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