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Postdoctoral Research Fellow

The University of Edinburgh - College of Medicine and Veterinary Medicine, Edinburgh Medical School: Biomedical Sciences, Centre for Discovery Brain Sciences

Location: Edinburgh
Salary: £37,099 to £44,263
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 8th December 2023
Closes: 29th January 2024
Job Ref: 9198

Contract Type - Fixed term, 48 months with possible extension 

Full time - 35 Hours  Per Week

We are looking for a postdoctoral research fellow in systems neuroscience to study how distributed neural circuits combine to plan, initiate, and control motor actions. 

The candidate will join our multi-disciplinary research team of cellular and circuit neurophysiologists who employ advanced in vivo 2-photon imaging (voltage/calcium), patch-clamp electrophysiology and high-density extracellular recordings combined with optogenetics and quantitative behaviour (https://duguidlab.com). We promote a team based approach to science in a highly collaborative environment that takes advantage of a wealth of groups working on cellular and systems neuroscience research in the Centre for Discovery Brain Sciences (https://discovery-brain-sciences.ed.ac.uk) and Simons Initiative for the Developing Brain (https://sidb.org.uk/) at The University of Edinburgh. 

The Opportunity:

Executing appropriately timed, reproducible actions is essential for interacting with our environment and ultimately survival. The goal of this project is to determine how we plan, initiate, and adapt motor actions depending on task requirements. This is thought to involve the interaction of both cortico-basal ganglia- and cortico-cerebellar-thalamocortical circuits, with ventral thalamus acting as a central hub to link subcortical and cortical motor areas. However, a causal mechanistic understanding of how these circuits combine to control purposive actions remains unresolved. To address this, we will combine advanced optical and neural recording techniques, viral-based manipulations, in silico modelling and quantitative behaviour in mice trained to perform a skilled object manipulation task. If you are interested in our approaches to understanding how the brain generates and controls movement and would like to know more, you can contact me at Ian.Duguid@ed.ac.uk or DM me on X (Ian_Duguid). 

Your skills and attributes for success:

  • A PhD in Neuroscience or related subject.
  • Experience in quantitative analysis of rodent behaviour. 
  • Experience in In vivo electrophysiology and/or 2-photon imaging. 
  • Analysis of electrophysiology and/or imaging timeseries data.
  • Small animal microsurgery.
  • Demonstrable fluency in the Python (or related) programming language.
  • Working knowledge of statistics. 
  • Excellent verbal and written communication skills.
  • Ability to work collaboratively as part of a larger research team.
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