Research Fellow

About us

The mission of the UCL GOS Institute of Child Health is to maximise and advocate for the holistic health of all children, young people and the adults they will become, through world-class research, education and public engagement. The UCL GOS ICH, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children’s health research outside North America. The 2024-29 GOS ICH strategy focuses on its five scientific programmes. GOS ICH’s activities include active engagement with children and families, to ensure that our work is relevant and appropriate to their needs. GOS ICH generates the funding for our research by setting out our proposals in high quality applications to public, charitable and industrial funding bodies and disseminates the results of our research by publication in the medical and scientific literature, to clinicians, policy makers and the wider public. Th e Institute offers world-class education and training across a wide range of teaching and life learning programmes which address the needs of students and professional groups who are interested in and undertaking work relevant to child health. GOS ICH holds an Athena SWAN Charter Gold Award.

About the role

A Research Fellow is required for a project investigating the use of CAR T cells as targeted conditioning prior to stem cell gene therapy. The postholder will support researchers testing this approach and investigate if epitope editing gene-corrected stem cells to render them resistant to CAR T cells allows selective expansion of corrected cells in vivo. If successful, this work will provide the scientific platform for testing this approach in clinical studies. The post is funded by GOSHCC and will be for 2 years. This will include 1 year working at Boston Children’s Hospital in the laboratory of Dr Pietro Genovese who has pioneered epitope editing and a ye ar at UCL GOS ICH working in Professor Persis Amrolia’s group, who have extensive expertise of CAR T cell therapy.

About you

The key requirements for the postholder are experience of molecular biology, culture/manipulation of primary cells, flow cytometry. Experience of murine work. Detailed knowledge or experience of gene editing, cellular immunology, CAR T cell and haemopoietic stem cell biology. Ability to design, undertake and analyse experiments independently, evidence of scientific output. Please check JD for detailed information.

What we offer

Visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more.

Our commitment to Equality, Diversity and Inclusion

As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce. These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women. You can read more about our commitment to Equality, Diversity and Inclusion here : https://www.ucl.ac.uk/equality-diversity-inclusion/ If you have any queries regarding the application process, please contact Madhur Sharma on ich.hr@ucl.ac.uk quoting job reference: B02-08715

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