Postdoctoral Researcher

Full-time (part-time considered)

Grade 7 (sp 29-36): £34,308 - £42,155

We are seeking a highly motivated Postdoctoral Researcher with experience in primary/stem cell culture along with a genuine passion for science, to join Dr James Cantley’s laboratory (Islet Biology) at the School of Medicine. The post is available from April 2023 for up to 5 years.

You will become a key member of an active and expanding research group, where you will be responsible for helping deliver an ambitious project investigating therapeutic strategies to regenerate pancreatic beta cells in the context of type 1 diabetes. You’ll work closely with the PI (Dr. Cantley) providing day-to-day guidance for a research assistant and PhD student. You will interact regularly with the project bioinformatician, wider Cantley lab and key internal/external collaborators.

You will lead the development, validation, and execution of cell-based multi-well assays, incorporating techniques including FACS, imaging and immunofluorescence. You’ll also conduct in vivo metabolic phenotyping of in vivo models, analysis of cells and tissues, histology, lab organisation, training, and day-to-day running of the laboratory. You will be adaptable and responsive to the needs of this fast-paced project to ensure that milestones and deadlines are met and that the project timetable stays on track.

This is an excellent opportunity to undertake cutting edge biomedical research in a world class environment, develop skills in early-stage drug discovery, metabolism and endocrinology, and to contribute to an area of significant unmet medical need, leading to new therapeutic approaches for type 1 diabetes. Experience with assay development (especially using live cell, imaging or phenotypic readouts), is an advantage.

Your priorities will include:

• Play a key role in delivering an ambitious project focussed on the development of therapeutic strategies to regenerate pancreatic beta cells during T1D, ensuring that project milestones and deadlines are met and that the project timetable stays on track.
• Develop, validate, and execute cell-based multi-well assays (low, medium and high throughput) using primary and stem cells.
• Analysis of cells and tissues using techniques including FACS, live cell imaging, transcriptomics, proteomics, histology and immunofluorescence.
• Contribute to in vivo metabolic phenotyping of in vivo models.
• Provide day-to-day guidance and supervision of a research assistant and PhD student.

Who we’re looking for:

• Hold a degree or equivalent qualification in a relevant biomedical (or related) subject.
• Experience generating, culturing and/or studying primary cells or stem cells.
• Experience running multi-well plate-based assays and analysing/interpreting data.
• Hard working, with a positive attitude and the ability to manage research and administrative activities and to meet deadlines to deliver complex biomedical projects.
• Excellent communication skills, including the ability to write text that can be published, present research proposals and results, work productively with team members/collaborators, and represent the research group at meetings.

The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff support networks for BME and LGBT staff, membership of Athena Swan and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.

Informal enquiries are welcome and should be addressed to Dr. James Cantley – jcantley001@dundee.ac.uk

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