Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenges.
About the Role:
A Senior Bioinformatician role funded by Open Targets is available at the Wellcome Sanger Institute under the leadership of Dr. Maya Ghoussaini for a 2 year fixed term contract.
Open Targets has launched Open Targets Genetics, a portal that aggregates large scale GWAS data with functional genomics data to identify potential drug targets at disease-associated loci.
You will be responsible for:
This is an exciting opportunity for you to participate in the enhancement of the Open Targets Genetics Portal through the development of new functionality and features using state of the art statistical genetics analysis.
You will actively engage in the integration of data from several genetic analyses including rare variant association analyses, burden tests in large-scale datasets such as the UK Biobank, and tissue enrichment analyses.
You will have the opportunity to work across a range of analyses including:
Use of rare and expert-curated loss-of-function (LoF) variants to inform drug target identification, prioritisation and safety.
Enhance our Machine Learning approaches to refine the prioritisation of genes at GWAS-associated loci by incorporating associations from rare variants.
Integrate genetic and cell-specific genomic data to identify and validate causal links between targets and diseases.
Perform association analysis on UK Biobank data with a particular focus on therapeutic areas important for Open Targets.
Work together with other members of the Open Targets team on statistical genetics analysis for large scale sequence analysis.
In this role, you will develop and apply computational pipelines to elucidate causal mechanisms through integrative analyses of data from GWAS, rare variants and burden tests, eQTL/pQTL, chromatin interactions and conformation, biobanks, and other related sources to identify and prioritise drug targets. You will use your existing expertise in genetics to design and implement appropriate solutions, and will keep up to date with developments in the fast moving field.
You will also have the opportunity to interact with active computational and experimental research teams using cutting edge genomic techniques across the Sanger Institute and Open Targets and work at the interface between academia and industry. You will work closely with members of the Open Targets Core Platform Team and Genetics Team as well as with our national and international collaborators.
You will be supported in your personal and professional development and have the opportunity to lead peer-reviewed publications around using genetics and genomics approaches to guide drug discovery and present them at national and international conferences.
MSc in Bioinformatics, or a closely related discipline or equivalent experience.
Advanced level programming skills suitable for genetic and computational analyses, such as Python or R.
Previous experience in working with large-scale genetic datasets.
Firm grounding with statistical methods of complex and rare disease genetics such as genome wide association studies, whole exome/genome sequencing analyses, identification and quality control of rare variants.
Ability to work to tight timelines.
Demonstrable project management and organisational skills.
Fluent in written and spoken English.
Ability to communicate ideas and results effectively.
Ability to work independently and organise own workload.
We have a flexible-hybrid working pattern model to allow you to work flexibly between home and office working.
Please apply with your CV and a cover letter outlining how you meet the criteria set out above.
Applications will be reviewed on an ongoing basis and the role may close early when a successful appointment has been made.
Working at Wellcome Sanger:
Our flexible-hybrid working environment is designed to support a healthy work-life balance. This means you can work flexibly with a combination of working from home, and working from our Campus to allow you to focus on being productive and part of the team while enjoying the benefits of working flexibly.
We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks, LGBTQ+, Parents and Carers and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others.
We want our people to be whoever they want to be because we believe people who bring their best selves to work, do their best work. That’s why we’re committed to creating a truly inclusive culture at Sanger Institute. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.
We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme. The importance of good health and adopting a healthier lifestyle and the commitment to reduce work-related stress is strongly acknowledged and recognised at Sanger Institute.
|Salary:||£43,597 to £51,794 (dependent upon skills and experience)|
|Placed On:||10th March 2023|
|Closes:||6th April 2023|
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